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GLP-1 receptor agonists like Wegovy and Mounjaro show the highest efficacy in clinical trials

maintaining benefits requires ongoing supplementation or periodic cycles

Retatrutide is an investigational triple GIP/GLP-1/glucagon receptor agonist and currently provides the strongest clinical support for the glucagon paradox

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However, its clinical impact, in terms of numbers needed to treat (NNT), efficacy and safety profile in reducing the risk of myocardial infarction (MI) and the individual ASCVD constituents remain unclear

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